Sulfonamides were the
first effective chemotherapeutic agents used systematically for the prevention
and cure a wide range of infections in human and other animal systems.
Heterocyclic sulfonamide derivatives are used as antidiabetic, antithyroid,antitumor,and
Sulfapyridine (SPY) is one of the important members of sulfa drugs.
Sulfapyridinewas the first synthetic antibacterial agent effective against pneumonia8-10.metal complexes of
heterocyclic compounds containing nitrogen, sulfur, and/or oxygen as ligand
atoms has attracted much attention. The ability of metal ions to bind in vivo
with proteinsand peptides is ansignificant feature of metal-baseddrugs.The
metal complex of sulfonamides appear a better activity than the free ligand at
the same experimental conditions 11,12.Metal-based drugs are widely used for the therapy and diagnosis
of a range of diseases13.
In the present study we are synthesis and spectroscopic characterization
of a new Cd complex with sulfapyridine as ligand with formula C16H15Cd0.50N4O2S. The crystal structure
was determined by single-crystal X-ray diffraction methods.
(Sigma Aldrich), cadmium perchlorate hydrate (
)and all other reagents are of the highest grade e quality, obtained
from commercial sources and used without further purification.
(2 mmol) is dissolved in hot methanol andNaOH is added, an aqueous solution of cadmium perchlorate
hydrate (1 mmol) is added with constant stirring and the mixture is refluxed
for about 3 h.A white precipitate is formed, filtered and washed with methanol
and distilled water successively and dried in a desiccator over anhydrous CaCl2.The
product is insoluble in water and in most common solvents but soluble inDMSO,
DMF, ?-picoline and pyridine. After many unsuccessful attempts,it was
possible to grow a few tiny colorless crystals of cadmium complex of
sulfapyridine (cdspy) from pyridine solution. Elemental analysis calculated for
(C16H15Cd0.50N4O2S): C, H, N %; found: C,H, N %.